Forecasting Seasonal Trends in Ear Nose Throat Diseases: A Comparative Analysis of Statistical and Machine Learning Models

Forecasting Seasonal Trends in ENT Diseases: A Comparative Analysis of Statistical and Machine Learning Models

  • Phuc Tran Huu Le
  • Huynh Nguyen Khanh Tran
  • Le Viet Ha Tran
  • Luong Hoang
Keywords: seasonal disease forecasting, machine learning and statistical forecasting, environmental correlation in healthcare

Abstract

This study examines patterns of seasonal illnesses at an ENT hospital using statistical methods and
advanced machine learning techniques to improve disease prediction and support healthcare planning. The
data underwent careful cleaning to ensure accuracy, which involved identifying outliers, managing missing
values, and normalizing information. The study looked at how seasonal illnesses develop, using a mix of
techniques. This research used advanced tools like Long Short-Term Memory (LSTM) networks and
Prophet, as well as simpler models such as Holt-Winters and SARIMA. To make the models easier to
understand, there is an application of SHAP (SHapley Additive Explanations) values. Finally, these
statistical measures like Mean Absolute Error (MAE) and confidence periods had been used to check the
accuracy of the forecasts at some stage in the overall performance assessment. Moreover, to discover how
weather influences sickness seasonality, connections between patterns of contamination and environmental
variables like temperature, humidity, and rainfall have been additionally looked at with the aid of the usage
of correlation prediction. In well-known, this blended method shows how conventional and system gaining
knowledge of models can monitor seasonal illness traits. The effects not simplest display disorder styles,
but in addition they assist with allocating resources and making guidelines for better healthcare
management.

Author Biographies

Phuc Tran Huu Le

Phuc Le Tran Huu obtained his Doctor of Science in Chemical Engineering from Yeungnam University, Korea, where he conducted research on automation and safety systems using the Haar-Cascade algorithm. He also holds a Master’s degree in Computer Engineering from the same university, and a Bachelor’s degree in Information Systems from the University of Missouri – St. Louis, USA. Currently, he is a lecturer at FPT University, Greenwich Vietnam, Hochiminh Campus. His research interests focus on artificial intelligence in healthcare, machine learning for smart systems, IoT-based environmental monitoring, and digital  transformation. He has led multiple projects in AI-powered diagnostics, smart factories, and energy- optimized buildings, and has published in both international conferences and journals.
Email: phuclth5@fe.edu.vn

Huynh Nguyen Khanh Tran

Huynh Nguyen Khanh Tran graduated in Organic Chemistry at the University of Science-Vietnam National University Ho Chi Minh City, Vietnam and earned the Master & PhD degree in Pharmacy in 2019 with Prof. Byung Sun Min at the Daegu Catholic University, Korea. He worked as a postdoctoral scientist at the Korea Institute of Science and Technology (KIST- Prof. Yang Hyun Ok) and then the Korea Institute of Ocean Science and Technology (KIOST- Prof. Yeon-Ju Lee), Korea. Currently, Dr. Tran serves as a lecturer at the Faculty of Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh City (VNUHCM), Vietnam. His research interest in Natural Products and their bioactivities on sources of herbal, marine sponges and fungi.
Email: thnkhanh@uhsvnu.edu.vn

Le Viet Ha Tran

Le Viet Ha Tran graduated in Biotechnology from the Ho Chi Minh City University of Technology, Vietnam, in 2015 and obtained her M.Sc. in 2020 at Daegu Catholic University, Korea. From March 2022 to 2024, she served as a research scientist in the Laboratory of Biotechnology and Marine Bioresources, Korea Institute of Ocean Science and Technology (KIOST), Korea. Now, she is serving as a researcher at University of Medicine and Pharmacy at Ho Chi Minh City. Her research interests are in Natural Products Chemistry.
Email: tlvha@ump.edu.vn

Luong Hoang

Luong Hoang received his Doctor of Medicine degree from the University of Medicine and Pharmacy at Ho Chi Minh City in 1985, and later completed his Ph.D. in Otorhinolaryngology in 2009. He currently serves as Director of the Saigon Ear, Nose and Throat Hospital. His previous roles include Vice Director in charge of
professional affairs at University Medical Center Ho Chi Minh City – Campus 2, and Senior Lecturer at the University of Medicine and Pharmacy at Ho Chi Minh City. His clinical and research expertise focuses on optic nerve decompression surgery for post-traumatic blindness, endoscopic sinus surgery, ear surgery, laryngeal surgery, and facial cosmetic procedures.
Email: bs.Luong@taimuihongsg.com

References

S. Wang, C. H. Lai, and W. Y. Shih, “Forecasting weekly outpatient visits using arima and holt–winters,” PLoS One, vol. 15, no. 5, p. e0232270, 2020.

C. Li, J. Lin, and W. Cao, “Time series analysis of infectious diseases in china: forecasting using the arima and holt–winters methods,” Infectious Diseases of Poverty, vol. 8, no. 1, p. 7, 2019.

T. H. Musa, S. T. Tay, Y. Lim, and M. R. Jumat, “Time series analysis of dengue fever in malaysia: comparison between arima and holt–winters models,” PLoS Neglected Tropical Diseases, vol. 14, no. 10, p. e0008680, 2020.

X. Zhou, Y. Zhang, Z. Li, et al., “Comparison of arima and holt–winters methods for predicting influenza outpatients in china,” Scientific Reports, vol. 8, no. 1, p. 16485, 2018.

M. Llamas-Nistal, J. A. Guitián, and V. Ríos, “Predicting the incidence of covid-19 using holt–winters and arima: the case of spain,” PLoS One, vol. 16, no. 4, p. e0250406, 2021.

Y. Liu, X. Zhang, Z. Wang, et al., “Comparison of arima and holt–winters models for predicting tuberculosis incidence in a chinese province,” BMC Infectious Diseases, vol. 20, no. 1, p. 50, 2020.

P. Guo, X. Li, Y. Zhang, et al., “A comparative study on time series forecasting models for hand, foot and mouth disease,” Frontiers in Public Health, vol. 8, p. 251, 2020.

N. D. Thanh, N. T. Luan, N. T. Thu, and N. T. Van, “Comparison of arima and holt–winters models for forecasting dengue fever in hanoi, vietnam,” International Journal of Infectious Diseases, vol. 85, pp. 117–124, 2019.

C. L. Poh, K. L. Thong, and H. Y. Chee, “Time series analysis of dengue fever cases in malaysia using the holt–

winters method,” Asia Pacific Journal of Public Health, vol. 31, no. 6, pp. 545–552, 2019.

W. Pan and Y. Li, “Comparison of the holt–winters and arima models in forecasting infectious disease,” Journal of Computer Science & Health Informatics, vol. 12, no. 1, pp. 44–50, 2019.

S. M. Lundberg and S. I. Lee, “A unified approach to interpreting model predictions,” Advances in Neural Information Processing Systems, vol. 30, pp. 4765–4774, 2017.

R. J. Hyndman and G. Athanasopoulos, Forecasting: Principles and Practice. OTexts, 3rd ed., 2021.

Published
2025-06-23